Nafadotride

• Supplier: Tocris Bioscience
• Catalog: 5515
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 149649-22-9
• Chemical Name: N-[(1-Butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy-2-naphthalenecarboxamide
• Formula: C22H27N3O2
• Molecular Weight: 365.47
• Purity: >98 %
• Description: Highly potent, competitive, preferential dopamine D 3 receptor antagonist. K i values are 0.52, 5, and 269 nM for human cloned D 3 , D 2 and D 4 receptors respectively. Centrally active upon systemic administration.

Product References

Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates - Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates

Sautel F, Griffon N, Sokoloff P, Schwartz JC, Launay C, Simon P, Costentin J, Schoenfelder A, Garrido F, Mann A, et al.. J Pharmacol Exp Ther. 1995 Dec;275(3):1239-46.

A comparative in vitro and in vivo pharmacological characterization of the novel - A comparative in vitro and in vivo pharmacological characterization of the novel

Audinot V, Newman-Tancredi A, Gobert A, Rivet JM, Brocco M, Lejeune F, Gluck L, Desposte I, Bervoets K, Dekeyne A, Millan MJ. J Pharmacol Exp Ther. 1998 Oct;287(1):187-97.

The dopamine D3 receptor antagonist nafadotride inhibits development of locomotor - The dopamine D3 receptor antagonist nafadotride inhibits development of locomotor

Richtand NM, Logue AD, Welge JA, Perdiue J, Tubbs LJ, Spitzer RH, Sethuraman G, Geracioti TD. Brain Res. 2000 Jun 9;867(1-2):239-42.