Narciclasine

Name	Narciclasine
Supplier	Tocris Bioscience
Catalog	2655
Prices	$165.00
Sizes	1 mg
Cas Number	29477-83-6
Chemical Name	(2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one
Formula	C14H13NO7
Molecular Weight	307.26
Purity	>98 %
Description	Exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC 50 = 47 nM). Activity decreases rate of cell division and increases mitosis duration in vitro . Also modulates the Rho/ROCK/LIM kinase/cofilin pathway; stimulates RhoA activation and induces actin polymerization.
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Product References

The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of - The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of

Dumont P, Ingrassia L, Rouzeau S, Ribaucour F, Thomas S, Roland I, Darro F, Lefranc F, Kiss R. Neoplasia. 2007 Sep;9(9):766-76.

Structure-activity relationship analysis of novel derivatives of narciclasine (an - Structure-activity relationship analysis of novel derivatives of narciclasine (an

Ingrassia L, Lefranc F, Dewelle J, Pottier L, Mathieu V, Spiegl-Kreinecker S, Sauvage S, El Yazidi M, Dehoux M, Berger W, Van Quaquebeke E, Kiss R. J Med Chem. 2009 Feb 26;52(4):1100-14.

Narciclasine, a plant growth modulator, activates Rho and stress fibers in - Narciclasine, a plant growth modulator, activates Rho and stress fibers in

Lefranc F, Sauvage S, Van Goietsenoven G, Megalizzi V, Lamoral-Theys D, Debeir O, Spiegl-Kreinecker S, Berger W, Mathieu V, Decaestecker C, Kiss R. Mol Cancer Ther. 2009 Jul;8(7):1739-50.