NAS-181

• Supplier: Tocris Bioscience
• Catalog: 3715
• Prices: $225.00, $925.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1217474-40-2
• Chemical Name: (2R)-2-[[[3-(4-Morpholinylmethyl)-2H-1-benzopyran-8-yl]oxy]methyl]morpholinedimethanesulfonate
• Formula: C19H26N2O4.2CH3SO3H
• Molecular Weight: 538.63
• Purity: >97 %
• Description: Potent, selective antagonist at the rat 5-HT 1B receptor (K i = 47 nM). Increases synthesis and metabolism of 5-HT in the brain following systemic administration and improves passive avoidance retention performance in vivo . Increases subthalamic nucleus-triggered complex EPSCs and burst firing in SNr GABA neurons

Product References

(R)-(+)-2-[[[3-(Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl] morpholine - (R)-(+)-2-[[[3-(Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl] morpholine

Berg S, Larsson LG, Renyi L, Ross SB, Thorberg SO, Thorell-Svantesson G. J Med Chem. 1998 May 21;41(11):1934-42.

Enhanced 5-HT metabolism and synthesis rate by the new selective r5-HT1B receptor - Enhanced 5-HT metabolism and synthesis rate by the new selective r5-HT1B receptor

Stenfors C, Yu H, Ross SB. Neuropharmacology. 2000 Feb 14;39(4):553-60.

Blockade of 5-HT 1B receptors facilitates contextual aversive learning in mice by - Blockade of 5-HT 1B receptors facilitates contextual aversive learning in mice by

Eriksson TM, Madjid N, Elvander-Tottie E, Stiedl O, Svenningsson P, Ogren SO. Neuropharmacology. 2008 Jun;54(7):1041-50.

Presynaptic serotonergic gating of the subthalamonigral glutamatergic projection. - Presynaptic serotonergic gating of the subthalamonigral glutamatergic projection.

Ding S, Li L, Zhou FM. J Neurosci. 2013 Mar 13;33(11):4875-85.