Naspm trihydrochloride

Name Naspm trihydrochloride
Supplier Tocris Bioscience
Catalog 1413
Prices $199.00
Sizes 10 mg
Function Type Antagonist
Cas Number 1049731-36-3
Chemical Name N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamidetrihydrochloride
Formula C22H34N4O.3HCl
Molecular Weight 479.91
Purity >97 %
Description Selective antagonist of Ca 2+ -permeable AMPA receptors; blocks AMPA receptors lacking the GluR2 subunit. Protects hippocampal neurons against global ischemia-induced cell death.
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Product References

Effects of a spider toxin and its analogue on glutamate-activated currents in the - Effects of a spider toxin and its analogue on glutamate-activated currents in the

Tsubokawa H, Oguro K, Masuzawa T, Nakaima T, Kawai N. J Neurophysiol. 1995 Jul;74(1):218-25.

Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors - Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors

Koike M, Iino M, Ozawa S. Neurosci Res. 1997 Sep;29(1):27-36.

A subtype-selective, use-dependent inhibitor of native AMPA receptors. - A subtype-selective, use-dependent inhibitor of native AMPA receptors.

Nilsen A, England PM. J Am Chem Soc. 2007 Apr 25;129(16):4902-3. Epub 2007 Mar 29.