NBI 31772

• Supplier: Tocris Bioscience
• Catalog: 1591
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 374620-70-9
• Chemical Name: 1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylicacid
• Formula: C17H11NO7
• Molecular Weight: 341.27
• Purity: >98 %
• Description: High affinity insulin-like growth factor-1 binding protein (IGFBP) inhibitor (K i values are 1 - 24 nM for all six human subtypes). Displaces insulin-like growth factor-1 (IGF-1) from the IGF-1:IGFBP complex and suppresses IGF1-induced proliferation of 3T3 fibroblasts. Also increases cardiomyocyte proliferation in vivo .

Product References

Discovery of a series of nonpeptide small molecules that inhibit the binding of - Discovery of a series of nonpeptide small molecules that inhibit the binding of

Chen C, Zhu YF, Liu XJ, Lu ZX, Xie Q, Ling N. J Med Chem. 2001 Nov 8;44(23):4001-10.

In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers - In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers

Choi WY, Gemberling M, Wang J, Holdway JE, Shen MC, Karlstrom RO, Poss KD. Development. 2013 Feb 1;140(3):660-6.