NBI 35965 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 5192
• Prices: $205.00, $845.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1782228-59-4
• Chemical Name: (7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylenehydrochloride
• Formula: C21H22Cl2N4.HCl
• Molecular Weight: 437.79
• Purity: >98 %
• Description: Potent and selective corticotropin-releasing factor receptor 1 (CRF 1 ) antagonist (K i values are 4 and > 10000 nM at CRF 1 and CRF 2 respectively). Inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro (pIC 50 values are 7.1 and 6.9 respectively) and attenuates CRF and ACTH production in vivo . Orally active and brain penetrant with anxiolytic activity.

Product References

Mechanism of corticotropin-releasing factor type I receptor regulation by - Mechanism of corticotropin-releasing factor type I receptor regulation by

Hoare SR, Sullivan SK, Ling N, Crowe PD, Grigoriadis DE. Mol Pharmacol. 2003 Mar;63(3):751-65.

A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts - A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts

Million M, Grigoriadis DE, Sullivan S, Crowe PD, McRoberts JA, Zhou H, Saunders PR, Maillot C, Mayer EA, Tache Y. Brain Res. 2003 Sep 19;985(1):32-42.

Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists. - Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists.

Gross RS, Guo Z, Dyck B, Coon T, Huang CQ, Lowe RF, Marinkovic D, Moorjani M, Nelson J, Zamani-Kord S, Grigoriadis DE, Hoare SR, Crowe PD, Bu JH, Haddach M, McCarthy J, Saunders J, Sullivan R, Chen T, Williams JP. J Med Chem. 2005 Sep 8;48(18):5780-93.