(±)-NBI 74330

Name	(±)-NBI 74330
Supplier	Tocris Bioscience
Catalog	3100
Prices	$265.00
Sizes	10 mg
Function Type	Antagonist
Cas Number	473722-68-8
Chemical Name	N-1-[(3-4(-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-4-fluoro-N-(3-pyridinylmethyl)-3-(trifluoromethyl)benzeneacetamide
Formula	C32H27F4N5O3
Molecular Weight	605.58
Purity	>98 %
Description	Potent and selective CXCR3 antagonist; potently inhibits 125 I-CXCL10 binding to CXCR3 (pK i = 8.13). Inhibits calcium mobilization in response to CXCL11 and CXCL10 in RBL cells. Exhibits no significant effect on chemotaxis induced by CXCR4 or CCR7. Displays a five-fold greater affinity for CXCR3 than (±)-AMG 487 (Cat. No. 4487).
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Product References

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Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and - Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and

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Noncompetitive antagonism and inverse agonism as mechanism of action of - Noncompetitive antagonism and inverse agonism as mechanism of action of

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