| Name | NDT 9513727 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4537 |
| Prices | $255.00, $1,045.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Antagonist |
| Cas Number | 439571-48-9 |
| Chemical Name | N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine |
| Formula | C36H35N3O4 |
| Molecular Weight | 573.68 |
| Purity | >98 % |
| Description | Potent C5a receptor (C5aR) competitive antagonist (IC 50 = 11.6 nM); selective for human C5aR (IC 50 values for rat and mouse C5aR are > 10 μ M). Exhibits inverse agonist pharmacokinetics. Blocks degranulation response in C5a-stimulated U937 cells (IC 50 = 7.1 nM). Orally bioavailable. |
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