NECA

• Supplier: Tocris Bioscience
• Catalog: 3517
• Prices: $59.00, $205.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 35920-39-9
• Chemical Name: 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-β-D-ribofuranuronamide
• Formula: C12H16N6O4
• Molecular Weight: 308.3
• Purity: >99 %
• Description: High affinity adenosine receptor agonist (K i values are 6.2, 14, and 20 nM for human A 3 , A 1 and A 2A receptors respectively; EC 50 = 2.4 μ M for human A 2B ). Inhibits platelet aggregation and is centrally active in vivo .

Product References

5'-N-ethylcarboxamidoadenosine: a potent inhibitor of human platelet aggregation. - 5'-N-ethylcarboxamidoadenosine: a potent inhibitor of human platelet aggregation.

Cusack NJ, Hourani SM. Br J Pharmacol. 1981 Mar;72(3):443-7.

Adenosine receptors and their ligands. - Adenosine receptors and their ligands.

Klotz KN. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):382-91.

Adenosine agonists CGS 21680 and NECA inhibit the initiation of cocaine - Adenosine agonists CGS 21680 and NECA inhibit the initiation of cocaine

Knapp CM, Foye MM, Cottam N, Ciraulo DA, Kornetsky C. Pharmacol Biochem Behav. 2001 Apr;68(4):797-803.