Necrostatin-1

• Supplier: Tocris Bioscience
• Catalog: 1691
• Prices: $109.00, $459.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 4311-88-0
• Chemical Name: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone
• Formula: C13H13N3OS
• Molecular Weight: 259.33
• Purity: >99 %
• Description: ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC 50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC 50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.

Product References

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for - Chemical inhibitor of nonapoptotic cell death with therapeutic potential for

Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Nat Chem Biol. 2005 Jul;1(2):112-9. Epub 2005 May 29.

Identification of RIP1 kinase as a specific cellular target of necrostatins. - Identification of RIP1 kinase as a specific cellular target of necrostatins.

Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Nat Chem Biol. 2008 May;4(5):313-21.

Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes - Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes

Linkermann A, Brasen JH, Himmerkus N, Liu S, Huber TB, Kunzendorf U, Krautwald S. Kidney Int. 2012 Apr;81(8):751-61.