Necrosulfonamide

• Supplier: Tocris Bioscience
• Catalog: 2324
• Prices: $95.00, $399.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1360614-48-7
• Chemical Name: (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide
• Formula: C18H15N5O6S2
• Molecular Weight: 461.47
• Purity: >98 %
• Description: Necroptosis inhibitor. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during necrosis. Prevents MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors.

Product References

Killing a cancer: what are the alternatives? - Killing a cancer: what are the alternatives?

Kreuzaler P, Watson CJ. Nat Rev Cancer. 2012 May 11;12(6):411-24.

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream - Mixed lineage kinase domain-like protein mediates necrosis signaling downstream

Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, Wang X. Cell. 2012 Jan 20;148(1-2):213-27.

New components of the necroptotic pathway. - New components of the necroptotic pathway.

Zhou Z, Han V, Han J. Protein Cell. 2012 Nov;3(11):811-7.