trans -Ned 19

• Supplier: Tocris Bioscience
• Catalog: 3953
• Prices: $299.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 1354235-96-3
• Chemical Name: (1R,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylicacid
• Formula: C30H31FN4O3
• Molecular Weight: 514.59
• Purity: >98 %
• Description: Nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Inhibits NAADP-mediated Ca 2+ release (IC 50 = 6 nM); also inhibits [ 32 P]NAADP binding (IC 50 = 0.4 nM). Fluorescently labels NAADP receptors in intact cells. Stereosiomer of cis -Ned 19 (Cat. No. 3953).

Product References

Identification of a chemical probe for NAADP by virtual screening. - Identification of a chemical probe for NAADP by virtual screening.

Naylor E, Arredouani A, Vasudevan SR, Lewis AM, Parkesh R, Mizote A, Rosen D, Thomas JM, Izumi M, Ganesan A, Galione A, Churchill GC. Nat Chem Biol. 2009 Apr;5(4):220-6.

Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist - Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist

Rosen D, Lewis AM, Mizote A, Thomas JM, Aley PK, Vasudevan SR, Parkesh R, Galione A, Izumi M, Ganesan A, Churchill GC. J Biol Chem. 2009 Dec 11;284(50):34930-4.

NAADP receptors mediate calcium signaling stimulated by endothelin-1 and - NAADP receptors mediate calcium signaling stimulated by endothelin-1 and

Thai TL, Churchill GC, Arendshorst WJ. Am J Physiol Renal Physiol. 2009 Aug;297(2):F510-6. doi: