Nefazodone hydrochloride

Name Nefazodone hydrochloride
Supplier Tocris Bioscience
Catalog 3954
Prices $129.00, $535.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 82752-99-6
Chemical Name 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-onehydrochloride
Formula C25H32ClN5O2.HCl
Molecular Weight 506.47
Purity >99 %
Description Serotonin 5-HT 2A receptor antagonist (K i = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC 50 values are 290 and 300 nM respectively). Displays no activity at 5-HT 1B and 5-HT 1D receptors. Active in models predictive of antidepressant potential.
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Product References

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Nefazodone. A review of its pharmacology and clinical efficacy in the management - Nefazodone. A review of its pharmacology and clinical efficacy in the management

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LY367265, an inhibitor of the 5-hydroxytryptamine transporter and - LY367265, an inhibitor of the 5-hydroxytryptamine transporter and

Pullar IA, Carney SL, Colvin EM, Lucaites VL, Nelson DL, Wedley S. Eur J Pharmacol. 2000 Oct 27;407(1-2):39-46.