Nemonapride

• Supplier: Tocris Bioscience
• Catalog: 3766
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 75272-39-8
• Chemical Name: cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]benzamide
• Formula: C21H26ClN3O2
• Molecular Weight: 387.91
• Purity: >99 %
• Description: Highly potent dopamine D 2 -like receptor antagonist; selective over D 1 -like receptors (K i values are 0.1 and 740 nM for D 2 -like and D 1 -like receptors respectively). Also potent 5-HT 1A receptor agonist (IC 50 = 34 nM) and has affinity for sigma receptors.

Product References

Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic - Selective binding of YM-09151-2, a new potent neuroleptic, to D2-dopaminergic

Terai M, Usuda S, Kuroiwa I, Noshiro O, Maeno H. Jpn J Pharmacol. 1983 Aug;33(4):749-55.

[3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma 1 and sigma 2 - [3H]YM-09151-2 (nemonapride), a potent radioligand for both sigma 1 and sigma 2

Ujike H, Akiyama K, Kuroda S. Neuroreport. 1996 Apr 10;7(5):1057-61.

5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison - 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison

Assie MB, Cosi C, Koek W. Eur J Pharmacol. 1997 Sep 10;334(2-3):141-7.