[D-Trp 34 ]-Neuropeptide Y

• Supplier: Tocris Bioscience
• Catalog: 1173
• Prices: $319.00
• Sizes: 200 µg
• Function Type: Agonist
• Cas Number: 153549-84-9
• Formula: C196H289N55O56
• Molecular Weight: 4311.77
• Description: Potent neuropeptide Y (NPY) Y 5 receptor agonist (pEC 50 values are 7.82, 6.28, 6.44 and > 6 at rat Y 5 , Y 4 , Y 1 and Y 2 receptors respectively) that displays > 26-fold, > 1000-fold and > 1000-fold selectivity over Y 1 , Y 2 and Y 4 receptors respectively. Induces hyperphagia, body weight gain, adiposity, hypercholesterolemia, hyperinsulinemia and hyperleptinemia in vivo . Orally active.

Product References

[D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide Y Y(5) receptor - [D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide Y Y(5) receptor

Parker EM, Balasubramaniam A, Guzzi M, Mullins DE, Salisbury BG, Sheriff S, Witten MB, Hwa JJ. Peptides. 2000 Mar;21(3):393-9.

Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice: - Characterization of neuropeptide Y (NPY) Y5 receptor-mediated obesity in mice:

Mashiko S, Ishihara A, Iwaasa H, Sano H, Oda Z, Ito J, Yumoto M, Okawa M, Suzuki J, Fukuroda T, Jitsuoka M, Morin NR, MacNeil DJ, Van der Ploeg LH, Ihara M, Fukami T, Kanatani A. Endocrinology. 2003 May;144(5):1793-801.

Responsiveness of obese Zucker rats to [D-Trp34]-NPY supports the targeting of Y5 - Responsiveness of obese Zucker rats to [D-Trp34]-NPY supports the targeting of Y5

Beck B, Richy S, Stricker-Krongrad A. Nutr Neurosci. 2007 Oct-Dec;10(5-6):211-4.