NF 023

• Supplier: Tocris Bioscience
• Catalog: 1909
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 104869-31-0
• Chemical Name: 8,8'-[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonicacid,hexasodiumsalt
• Formula: C35H20N4Na6O21S6
• Molecular Weight: 1162.86
• Description: A subtype-selective, competitive and reversible P2X 1 receptor antagonist. Displays IC 50 values of 0.21, 28.9, > 50 and > 100 μ M for human P2X 1 , P2X 3 , P2X 2 , and P2X 4 -mediated responses respectively. Selective over adrenoceptors, histamine and P2Y receptors. Also selectively inhibits the α -subunit of G o/i (EC 50 ~300 nM).

Product References

Novel competitive antagonists for P2 purinoceptors. - Novel competitive antagonists for P2 purinoceptors.

van Rhee AM, van der Heijden MP, Beukers MW, IJzerman AP, Soudijn W, Nickel P. Eur J Pharmacol. 1994 Jun 15;268(1):1-7.

Suramin analogues as subtype-selective G protein inhibitors. - Suramin analogues as subtype-selective G protein inhibitors.

Freissmuth M, Boehm S, Beindl W, Nickel P, Ijzerman AP, Hohenegger M, Nanoff C. Mol Pharmacol. 1996 Apr;49(4):602-11.

Antagonistic properties of the suramin analogue NF023 at heterologously expressed - Antagonistic properties of the suramin analogue NF023 at heterologously expressed

Soto F, Lambrecht G, Nickel P, Stuhmer W, Busch AE. Neuropharmacology. 1999 Jan;38(1):141-9.

The effect of P2 receptor antagonists and ATPase inhibition on sympathetic - The effect of P2 receptor antagonists and ATPase inhibition on sympathetic

Sneddon P, Westfall TD, Todorov LD, Todorova SM, Westfall DP, Nickel P, Kennedy C. Br J Pharmacol. 2000 Mar;129(6):1089-94.