NF 110

• Supplier: Tocris Bioscience
• Catalog: 1240
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 111150-22-2
• Chemical Name: 4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt
• Formula: C41H28N6Na4O17S4
• Molecular Weight: 1096.9
• Description: High affinity P2X 3 receptor antagonist (K i values are 36, 82 and 4144 nM for P2X 3 , P2X 1 and P2X 2 recombinant receptors respectively). Shows no activity at P2Y 1 , P2Y 2 and P2Y 11 receptors (IC 50 > 10 μ M). Potently inhibits α , β -meATP-evoked desensitizing currents in rat DRG neurons (IC 50 = 527 nM). Shows antitumor activity against several tumor types.

Product References

Antitumour activity of suramin analogues in human tumour cell lines and primary - Antitumour activity of suramin analogues in human tumour cell lines and primary

Dhar S, Gullbo J, Csoka K, Eriksson E, Nilsson K, Nickel P, Larsson R, Nygren P. Eur J Cancer. 2000 Apr;36(6):803-9.

Structure-activity relationships of analogues of NF449 confirm NF449 as the most - Structure-activity relationships of analogues of NF449 confirm NF449 as the most

Kassack MU, Braun K, Ganso M, Ullmann H, Nickel P, Boing B, Muller G, Lambrecht G. Eur J Med Chem. 2004 Apr;39(4):345-57.

The suramin analog 4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis - The suramin analog 4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis

Hausmann R, Rettinger J, Gerevich Z, Meis S, Kassack MU, Illes P, Lambrecht G, Schmalzing G. Mol Pharmacol. 2006 Jun;69(6):2058-67. Epub 2006 Mar 21.