NF 157

• Supplier: Tocris Bioscience
• Catalog: 2548
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 104869-26-3
• Chemical Name: 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-fluoro-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonicacidhexasodiumsalt
• Formula: C49H28F2N6Na6O23S6
• Molecular Weight: 1437.08
• Description: Purinergic receptor antagonist that potently inhibits P2Y 11 receptor activity (IC 50 = 463 nM). Displays selectivity for P2Y 11 and P2X 1 receptors over P2Y 1 , P2Y 2 , P2X 2 , P2X 3 , P2X 4 and P2X 7 receptors. Inhibits NAD + -induced activation of human granulocytes.

Product References

Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor - Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor

Ullmann H, Meis S, Hongwiset D, Marzian C, Wiese M, Nickel P, Communi D, Boeynaems JM, Wolf C, Hausmann R, Schmalzing G, Kassack MU. J Med Chem. 2005 Nov 3;48(22):7040-8.

Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human - Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human

Moreschi I, Bruzzone S, Nicholas RA, Fruscione F, Sturla L, Benvenuto F, Usai C, Meis S, Kassack MU, Zocchi E, De Flora A. J Biol Chem. 2006 Oct 20;281(42):31419-29. Epub 2006 Aug 22.