NF 279

• Supplier: Tocris Bioscience
• Catalog: 2450
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 202983-32-2
• Chemical Name: 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonicacidhexasodiumsalt
• Formula: C49H30N6Na6O23S6
• Molecular Weight: 1401.1
• Description: A potent and selective P2X 1 antagonist (IC 50 = 19 nM). Displays good selectivity over P2X 2 ,(IC 50 = 0.76 μ M), P2X 3 (IC 50 = 1.62 μ M), P2X 4 (IC 50 > 300 μ M), P2Y receptors and ecto-nucleotidases.

Product References

NF279: a novel potent and selective antagonist of P2X receptor-mediated - NF279: a novel potent and selective antagonist of P2X receptor-mediated

Damer S, Niebel B, Czeche S, Nickel P, Ardanuy U, Schmalzing G, Rettinger J, Mutschler E, Lambrecht G. Eur J Pharmacol. 1998 May 29;350(1):R5-6.

Antagonism by the suramin analogue NF279 on human P2X(1) and P2X(7) receptors. - Antagonism by the suramin analogue NF279 on human P2X(1) and P2X(7) receptors.

Klapperstuck M, Buttner C, Nickel P, Schmalzing G, Lambrecht G, Markwardt F. Eur J Pharmacol. 2000 Jan 17;387(3):245-52.

The suramin analogue NF279 is a novel and potent antagonist selective for the - The suramin analogue NF279 is a novel and potent antagonist selective for the

Rettinger J, Schmalzing G, Damer S, Muller G, Nickel P, Lambrecht G. Neuropharmacology. 2000 Aug 23;39(11):2044-53.