NG 25

• Supplier: Tocris Bioscience
• Catalog: 2789
• Prices: $289.00
• Sizes: 5 mg
• Function Type: Inhibitor
• Cas Number: 1315355-93-1
• Chemical Name: N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide
• Formula: C29H30F3N5O2
• Molecular Weight: 537.58
• Purity: >98 %
• Description: TGF- β -activated kinase (TAK1) inhibitor (IC 50 = 149 nM). Also inhibits LYN, MAP4K2 and Abl kinase activity (IC 50 values are 12.9, 21.7 and 75.2 nM, respectively). Suppresses CpG A and CpG B-stimulated secretion of IFN- α and TLR7/8 agonist CL097-stimulated secretion of IFN- β in Gen 2.2 leukemia cells in vitro .

Product References

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at - The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at

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Essential role for IKKbeta in production of type 1 interferons by plasmacytoid - Essential role for IKKbeta in production of type 1 interferons by plasmacytoid

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Discovery of type II inhibitors of TGFbeta-activated kinase 1 (TAK1) and - Discovery of type II inhibitors of TGFbeta-activated kinase 1 (TAK1) and

Tan L, Nomanbhoy T, Gurbani D, Patricelli M, Hunter J, Geng J, Herhaus L, Zhang J, Pauls E, Ham Y, Choi HG, Xie T, Deng X, Buhrlage SJ, Sim T, Cohen P, Sapkota G, Westover KD, Gray NS. J Med Chem. 2015 Jan 8;58(1):183-96.