NGB 2904

• Supplier: Tocris Bioscience
• Catalog: 5429
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 189061-11-8
• Chemical Name: N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide
• Formula: C28H29Cl2N3O.HCl
• Molecular Weight: 530.92
• Purity: >98 %
• Description: Potent and selective dopamine D 3 receptor antagonist (K i values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D 3 , D 2 , 5-HT 2 , α 1 , D 4 , D 1 and D 5 receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC 50 = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.

Product References

NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists. - NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists.

Yuan J, Chen X, Brodbeck R, Primus R, Braun J, Wasley JW, Thurkauf A. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2715-8.

The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding - The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding

Xi ZX, Newman AH, Gilbert JG, Pak AC, Peng XQ, Ashby CR Jr, Gitajn L, Gardner EL. Neuropsychopharmacology. 2006 Jul;31(7):1393-405. Epub 2005 Oct 5.

The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and - The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and

Pritchard LM, Newman AH, McNamara RK, Logue AD, Taylor B, Welge JA, Xu M, Zhang J, Richtand NM. Pharmacol Biochem Behav. 2007 Apr;86(4):718-26. Epub 2007 Mar 6.