NH 125

Name NH 125
Supplier Tocris Bioscience
Catalog 4315
Prices $169.00, $705.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 278603-08-0
Chemical Name 1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazoliumiodide
Formula C27H45IN2
Molecular Weight 524.56
Description Eukaryotic elongation factor 2 (eEF-2) kinase (CaMK III) inhibitor (IC 50 = 60 nM) that displays 125-fold, > 1300-fold and > 1500-fold selectivity over PKC, PKA and CaMK II respectively. Decreases the viability of a variety of cancer cell lines (IC 50 values are 0.7 - 4.8 μ M) and blocks G 1 /S cell cycle progression. Shown to induce eEF-2 phosphorylation in cancer cells. Also an effective antibacterial agent; inhibits histidine protein kinase in vitro (IC 50 = 6.6 μ M) and in vivo .
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Product References

Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus - Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus

Yamamoto K, Kitayama T, Minagawa S, Watanabe T, Sawada S, Okamoto T, Utsumi R. Biosci Biotechnol Biochem. 2001 Oct;65(10):2306-10.

Identification and characterization of an inhibitor of eukaryotic elongation - Identification and characterization of an inhibitor of eukaryotic elongation

Arora S, Yang JM, Kinzy TG, Utsumi R, Okamoto T, Kitayama T, Ortiz PA, Hait WN. Cancer Res. 2003 Oct 15;63(20):6894-9.

P-glycoprotein mediates resistance to histidine kinase inhibitors. - P-glycoprotein mediates resistance to histidine kinase inhibitors.

Arora S, Yang JM, Utsumi R, Okamoto T, Kitayama T, Hait WN. Mol Pharmacol. 2004 Sep;66(3):460-7.

1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of - 1-Benzyl-3-cetyl-2-methylimidazolium iodide (NH125) induces phosphorylation of

Chen Z, Gopalakrishnan SM, Bui MH, Soni NB, Warrior U, Johnson EF, Donnelly JB, Glaser KB. J Biol Chem. 2011 Dec 23;286(51):43951-8.