NHI 2

• Supplier: Tocris Bioscience
• Catalog: 3439
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1269802-97-2
• Chemical Name: Methyl1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylate
• Formula: C17H12F3NO3
• Molecular Weight: 335.28
• Purity: >98 %
• Description: LDHA inhibitor; reduces lactate production in HeLa cells. Inhibits cell growth of LPC006 and PANC-1 cells in vitro . Also enhances the antiproliferative effects of Gemcitabine (Cat. No. 3259) on LPC006 and PANC-1 cells.

Product References

Dual targeting of the Warburg effect with a glucose-conjugated lactate - Dual targeting of the Warburg effect with a glucose-conjugated lactate

Calvaresi EC, Granchi C, Tuccinardi T, Di Bussolo V, Huigens RW 3rd, Lee HY, Palchaudhuri R, Macchia M, Martinelli A, Minutolo F, Hergenrother PJ. Chembiochem. 2013 Nov 25;14(17):2263-7.

Assessing the differential action on cancer cells of LDH-A inhibitors based on - Assessing the differential action on cancer cells of LDH-A inhibitors based on

Granchi C, Calvaresi EC, Tuccinardi T, Paterni I, Macchia M, Martinelli A, Hergenrother PJ, Minutolo F. Org Biomol Chem. 2013 Oct 14;11(38):6588-96.

Synergistic interaction of novel lactate dehydrogenase inhibitors with - Synergistic interaction of novel lactate dehydrogenase inhibitors with

Maftouh M, Avan A, Sciarrillo R, Granchi C, Leon LG, Rani R, Funel N, Smid K, Honeywell R, Boggi U, Minutolo F, Peters GJ, Giovannetti E. Br J Cancer. 2014 Jan 7;110(1):172-82.