| Name | Niclosamide |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 0604 |
| Prices | $95.00 |
| Sizes | 50 mg |
| Function Type | Inhibitor |
| Cas Number | 50-65-7 |
| Chemical Name | 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide |
| Formula | C13H8Cl2N2O4 |
| Molecular Weight | 325.99 |
| Purity | >99 % |
| Description | Inhibitor of the STAT3 signaling pathway; inhibits the activation, nuclear translocation and transactivation of STAT3. Displays selectivity for STAT3 over STAT1, STAT5, JAK1, JAK2 and Src kinases. Inhibits the transcription of STAT3 target genes and induces cell growth inhibition, apoptosis and cell cycle arrest of cancer cells with constitutively active STAT3. Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro ; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells. |
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Balgi AD, Fonseca BD, Donohue E, Tsang TC, Lajoie P, Proud CG, Nabi IR, Roberge M. PLoS One. 2009 Sep 22;4(9):e7124.
Jin Y, Lu Z, Ding K, Li J, Du X, Chen C, Sun X, Wu Y, Zhou J, Pan J. Cancer Res. 2010 Mar 15;70(6):2516-27.