Nicorandil

Name Nicorandil
Supplier Tocris Bioscience
Catalog 4079
Prices $79.00
Sizes 50 mg
Cas Number 65141-46-0
Chemical Name N-[2-(Nitrooxy)ethyl]-3-pyridinecarboxamide
Formula C8H9N3O4
Molecular Weight 211.18
Description K ir 6 (K ATP ) channel opener and NO donor; antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing K ir 6 channels (EC 50 values are 10 and > 500 μ M respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.
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Product References

SUR2 subtype (A and B)-dependent differential activation of the cloned - SUR2 subtype (A and B)-dependent differential activation of the cloned

Shindo T, Yamada M, Isomoto S, Horio Y, Kurachi Y. Br J Pharmacol. 1998 Jul;124(5):985-91.

Potassium channel openers in myocardial ischaemia: therapeutic potential of - Potassium channel openers in myocardial ischaemia: therapeutic potential of

Gomma AH, Purcell HJ, Fox KM. Drugs. 2001;61(12):1705-10.

Nicorandil enhances cardiac endothelial nitric oxide synthase expression via - Nicorandil enhances cardiac endothelial nitric oxide synthase expression via

Horinaka S, Kobayashi N, Higashi T, Hara K, Hara S, Matsuoka H. J Cardiovasc Pharmacol. 2001 Aug;38(2):200-10.