Niflumic acid

Name Niflumic acid
Supplier Tocris Bioscience
Catalog 1075
Prices $45.00
Sizes 50 mg
Cas Number 4394-00-7
Chemical Name 2-[3-(Trifluoromethyl)anilino]nicotinicacid
Formula C13H9F3N2O2
Molecular Weight 282.22
Description Nonsteroidal anti-inflammatory drug (NSAID); selectively inhibits COX-2. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.
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Product References

Potentiation of large conductance KCa channels by niflumic, flufenamic, and - Potentiation of large conductance KCa channels by niflumic, flufenamic, and

Ottolia M, Toro L. Biophys J. 1994 Dec;67(6):2272-9.

In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 - In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2

Famaey JP. Inflamm Res. 1997 Nov;46(11):437-46.

Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. - Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs.

Hu H, Tian J, Zhu Y, Wang C, Xiao R, Herz JM, Wood JD, Zhu MX. Pflugers Arch. 2010 Mar;459(4):579-92.

Multiple tyrosine metabolites are GPR35 agonists. - Multiple tyrosine metabolites are GPR35 agonists.

Deng H, Hu H, Fang Y. Sci Rep. 2012;2:373.