( R )-(-)-Niguldipine hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4312
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 113145-70-3
• Chemical Name: (R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid,3-(4,4-diphenyl-1-piperidinyl)propylmethylesterhydrochloride
• Formula: C36H39N3O6.HCl
• Molecular Weight: 646.18
• Description: L-type Ca 2+ channel blocker and α 1A -adrenoceptor antagonist; less active enantiomer. ( S )-(+)-Niguldipine hydrochloride (Cat. No. 1123) also available.

Product References

(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype - (+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype

Boer R, Grassegger A, Schudt C, Glossmann H. Eur J Pharmacol. 1989 May 11;172(2):131-45.

Stereoselective binding of niguldipine enantiomers to alpha 1A-adrenoceptors - Stereoselective binding of niguldipine enantiomers to alpha 1A-adrenoceptors

Graziadei I, Zernig G, Boer R, Glossman H. Eur J Pharmacol. 1989 Oct 17;172(4-5):329-37.

Stereoisomers of calcium antagonists which differ markedly in their potencies as - Stereoisomers of calcium antagonists which differ markedly in their potencies as

Hollt V, Kouba M, Dietel M, Vogt G. Biochem Pharmacol. 1992 Jun 23;43(12):2601-8.

Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ - Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+

Wetzel JM, Miao SW, Forray C, Borden LA, Branchek TA, Gluchowski C. J Med Chem. 1995 May 12;38(10):1579-81.