Nilvadipine

Name Nilvadipine
Supplier Tocris Bioscience
Catalog 1759
Prices $99.00
Sizes 50 mg
Function Type Inhibitor
Cas Number 75530-68-6
Chemical Name 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid3-methyl5-(1-methylethyl)ester
Formula C19H19N3O6
Molecular Weight 385.37
Purity >99 %
Description Syk inhibitor. Blocks A β production, APP β secretion and reduces BACE-1 expression in CHO cells over-expressing A β in vitro . Enhances clearance of A β across the blood brain barrier in vivo . Reduces brain A β levels in a mouse tauopathy model. Also L-type calcium channel blocker and antihypertensive.
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Product References

In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 - In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2

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Selective cyclooxygenase-2 inhibition by nimesulide in man. - Selective cyclooxygenase-2 inhibition by nimesulide in man.

Cullen L, Kelly L, Connor SO, Fitzgerald DJ. J Pharmacol Exp Ther. 1998 Nov;287(2):578-82.