NKH 477

• Supplier: Tocris Bioscience
• Catalog: 3228
• Prices: $209.00, $879.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 138605-00-2
• Chemical Name: N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylesterβ-alaninehydrochloride
• Formula: C27H43NO8.HCl
• Molecular Weight: 546.1
• Purity: >98 %
• Description: Water-soluble analog of forskolin (Cat. No. 1099) that is a potent activator of adenylyl cyclase; shows some selectivity for cardiac (type V) adenylyl cyclase. Stimulates bronchodilation (EC 50 = 32.6 nM) and is an orally active potent positive chronotrope and hypotensive agent in vivo . Also available as part of the PKA Tocriset™ .

Product References

Cardiovascular and adenylate cyclase stimulant properties of NKH477, a novel - Cardiovascular and adenylate cyclase stimulant properties of NKH477, a novel

Hosono M, Takahira T, Fujita A, Fujihara R, Ishizuka O, Tatee T, Nakamura K. J Cardiovasc Pharmacol. 1992 Apr;19(4):625-34.

Relaxant effects of NKH477, a new water-soluble forskolin derivative, on - Relaxant effects of NKH477, a new water-soluble forskolin derivative, on

Satake K, Takagi K, Kodama I, Honjo H, Toyama J, Shibata S. Br J Pharmacol. 1998 Feb;123(4):753-61.

Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase. - Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase.

Toya Y, Schwencke C, Ishikawa Y. J Mol Cell Cardiol. 1998 Jan;30(1):97-108.