NNC 05-2090 hydrochloride

Name NNC 05-2090 hydrochloride
Supplier Tocris Bioscience
Catalog 0664
Prices $199.00, $825.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 184845-18-9
Chemical Name 1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinolhydrochloride
Formula C27H30N2O2.HCl
Molecular Weight 451.01
Purity >98 %
Description GABA uptake inhibitor that displays moderate selectivity for BGT-1 (mGAT-2) transporters (K i values are 1.4, 15, 19 and 41 μ M for hBGT-1, hGAT-3, hGAT-1 and hGAT-2 respectively). Anticonvulsive; inhibits sound-induced tonic and clonic convulsions in DBA/2 mice. Also displays affinity at α 1 - and D 2 -receptors (IC 50 values are 266 and 1632 nM respectively).
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Product References

Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC - Anticonvulsant properties of two GABA uptake inhibitors NNC 05-2045 and NNC

Dalby NO, Thomsen C, Fink-Jensen A, Lundbeck J, Sokilde B, Man CM, Sorensen PO, Meldrum B. Epilepsy Res. 1997 Jul;28(1):51-61.

1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel - 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel

Thomsen C, Sorensen PO, Egebjerg J. Br J Pharmacol. 1997 Mar;120(6):983-5.