NNC 26-9100

• Supplier: Tocris Bioscience
• Catalog: 2747
• Prices: $225.00
• Sizes: 10 mg
• Function Type: Agonist
• Cas Number: 199522-35-5
• Chemical Name: 1-[3-[N-(5-Bromopyridin-2-yl)-N-(3,4-dichlorobenzyl)amino]propyl]-3-[3-(1H-imidazol-4-yl)propyl]thiourea
• Formula: C22H25N6Cl2SBr
• Molecular Weight: 556.35
• Purity: >99 %
• Description: Somatostatin sst 4 receptor agonist that displays > 100-fold selectivity over sst 2 receptors (K i values are 6 and 621 nM for sst 4 and sst 2 receptors respectively). Potently inhibits forskolin-induced cAMP accumulation (EC 50 = 26 nM).

Product References

Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and - Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and

Liu S, Tang C, Ho B, Ankersen M, Stidsen CE, Crider AM. J Med Chem. 1998 Nov 19;41(24):4693-705.

2-pyridylthioureas: novel nonpeptide somatostatin agonists with SST4 selectivity. - 2-pyridylthioureas: novel nonpeptide somatostatin agonists with SST4 selectivity.

Liu S, Crider AM, Tang C, Ho B, Ankersen M, Stidsen CE. Curr Pharm Des. 1999 Apr;5(4):255-63.