NNC 711

• Supplier: Tocris Bioscience
• Catalog: 1780
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 145645-62-1
• Chemical Name: 1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylicacidhydrochloride
• Formula: C21H22N2O3.HCl
• Molecular Weight: 386.88
• Purity: >99 %
• Description: Potent and selective inhibitor of GABA uptake by GAT-1 (IC 50 values are 0.04, 171, 1700 and 622 μ M for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Anticonvulsant following systemic administration in vivo . Also exhibits cognition-enhancing activity.

Product References

NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor: - NNC-711, a novel potent and selective gamma-aminobutyric acid uptake inhibitor:

Suzdak PD, Frederiksen K, Andersen KE, Sorensen PO, Knutsen LJ, Nielsen EB. Eur J Pharmacol. 1992 Dec 2;224(2-3):189-98.

Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA - Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA

Borden LA, Murali Dhar TG, Smith KE, Weinshank RL, Branchek TA, Gluchowski C. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.

Anti-ischemic and cognition-enhancing properties of NNC-711, a gamma-aminobutyric - Anti-ischemic and cognition-enhancing properties of NNC-711, a gamma-aminobutyric

O'Connell AW, Fox GB, Kjoller C, Gallagher HC, Murphy KJ, Kelly J, Regan CM. Eur J Pharmacol. 2001 Jul 13;424(1):37-44.