[(pF)Phe 4 ]Nociceptin(1-13)NH 2

• Supplier: Tocris Bioscience
• Catalog: 1590
• Prices: $209.00
• Sizes: 1 mg
• Function Type: Agonist
• Cas Number: 380620-88-2
• Formula: C61H99FN22O15
• Molecular Weight: 1399.6
• Description: Highly potent and selective nociceptin/orphanin FQ receptor (OP 4 ) agonist peptide (pK i = 10.68; pEC 50 = 9.80). Displays > 8000-fold selectivity over δ , κ , and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotropic and feeding stimulation effects in vivo .

Product References

Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): - Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2):

Guerrini R, Calo G, Bigoni R, Rizzi D, Rizzi A, Zucchini M, Varani K, Hashiba E, Lambert DG, Toth G, Borea PA, Salvadori S, Regoli D. J Med Chem. 2001 Nov 8;44(23):3956-64.

Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. - Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1.

Bigoni R, Rizzi D, Rizzi A, Camarda V, Guerrini R, Lambert DG, Hashiba E, Berger H, Salvadori S, Regoli D, Calo' G. Naunyn Schmiedebergs Arch Pharmacol. 2002 Jun;365(6):442-9. Epub 2002 Apr 19.

Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)NH2 analogues. 2. - Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)NH2 analogues. 2.

Rizzi A, Salis MB, Ciccocioppo R, Marzola G, Bigoni R, Guerrini R, Massi M, Madeddu P, Salvadori S, Regoli D, Calo' G. Naunyn Schmiedebergs Arch Pharmacol. 2002 Jun;365(6):450-6. Epub 2002 Apr 19.