Nogo-66 (1-40)

Name Nogo-66 (1-40)
Supplier Tocris Bioscience
Catalog 1228
Prices $335.00
Sizes 1 mg
Cas Number 475221-20-6
Formula C206H324N56O65
Molecular Weight 4625.16
Description Peptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS myelin-induced inhibition of axonal growth, but does not reduce myelin-associated glycoprotein (MAG) inhibition of neurite outgrowth in vitro . Promotes regeneration of hemisected spinal axons and locomotor recovery following spinal injury in vivo .
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Product References

Nogo-66 receptor antagonist peptide promotes axonal regeneration. - Nogo-66 receptor antagonist peptide promotes axonal regeneration.

GrandPre T, Li S, Strittmatter SM. Nature. 2002 May 30;417(6888):547-51.

Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. - Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor.

Liu BP, Fournier A, GrandPre T, Strittmatter SM. Science. 2002 Aug 16;297(5584):1190-3. Epub 2002 Jun 27.

Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord - Delayed systemic Nogo-66 receptor antagonist promotes recovery from spinal cord

Li S, Strittmatter SM. J Neurosci. 2003 May 15;23(10):4219-27.