Noladin ether

• Supplier: Tocris Bioscience
• Catalog: 1984
• Prices: $139.00, $585.00
• Sizes: 5 mg, 25 mg
• Function Type: Agonist
• Cas Number: 222723-55-9
• Chemical Name: 2-[(5Z,8Z,11Z,14Z)-Eicosatetraenyloxy]-1,3-propanediol
• Formula: C23H40O3
• Molecular Weight: 364.57
• Description: Endogenous agonist for the GPR55 and CB 1 receptors (EC 50 values are 10 and 37 nM respectively) that displays selectivity over CB 2 receptors (K i values are 21.2 nM and > 3mM at CB 1 and CB 2 respectively). Causes sedation, hypothermia, intestinal immobility and mild antinociception in vivo . Attenuates sensory neurotransmission in rat mesenteric arteries via GPR55.

Product References

Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. - Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor.

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Synthesis and biological activities of 2-arachidonoylglycerol, an endogenous - Synthesis and biological activities of 2-arachidonoylglycerol, an endogenous

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2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 - 2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1

Hanus L, Abu-Lafi S, Fride E, Breuer A, Vogel Z, Shalev DE, Kustanovich I, Mechoulam R. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3662-5. Epub 2001 Mar 20.

Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission - Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission

Duncan M, Millns P, Smart D, Wright JE, Kendall DA, Ralevic V. Br J Pharmacol. 2004 Jun;142(3):509-18. Epub 2004 May 17.

The orphan receptor GPR55 is a novel cannabinoid receptor. - The orphan receptor GPR55 is a novel cannabinoid receptor.

Ryberg E, Larsson N, Sjogren S, Hjorth S, Hermansson NO, Leonova J, Elebring T, Nilsson K, Drmota T, Greasley PJ. Br J Pharmacol. 2007 Dec;152(7):1092-101. Epub 2007 Sep 17.