Nomifensine

• Supplier: Tocris Bioscience
• Catalog: 1411
• Prices: $109.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 32795-47-4
• Chemical Name: 1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinaminemaleate
• Formula: C16H18N2.C4H4O4
• Molecular Weight: 354.4
• Purity: >98 %
• Description: Potent inhibitor of noradrenalin and dopamine uptake (K i values are 4.7, 26 and 4000 nM for inhibition of noradrenalin, dopamine and 5-HT uptake respectively, in rat brain). Increases central dopamine levels in rats following systemic administration. Displays antidepressant activity.

Product References

Nomifensine and its derivatives as possible tools for studying amine uptake. - Nomifensine and its derivatives as possible tools for studying amine uptake.

Tuomisto J. Eur J Pharmacol. 1977 Mar 21;42(2):101-6.

Effects of various dopamine uptake inhibitors on striatal extracellular dopamine - Effects of various dopamine uptake inhibitors on striatal extracellular dopamine

Nakachi N, Kiuchi Y, Inagaki M, Inazu M, Yamazaki Y, Oguchi K. Eur J Pharmacol. 1995 Aug 4;281(2):195-203.

Effects of acute and sustained administration of the catecholamine reuptake - Effects of acute and sustained administration of the catecholamine reuptake

Katz NS, Guiard BP, El Mansari M, Blier P. J Psychopharmacol. 2010 Aug;24(8):1223-35.