Norketamine hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 5169
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 79499-59-5
• Chemical Name: 2-Amino-2-(2-chlorophenyl)cyclohexanonehydrochloride
• Formula: C12H14ClNO.HCl
• Molecular Weight: 260.16
• Purity: >99 %
• Description: Major metabolite of ketamine that is a potent non-competitive NMDA receptor antagonist (K i = 3.6 μ M for displacement of [ 3 H]-MK 801 in rat brain). Antinociceptive and anesthetic in vivo . R -enantiomer and S -enantiomer also available.

Product References

Comparative pharmacology in the rat of ketamine and its two principal - Comparative pharmacology in the rat of ketamine and its two principal

Leung LY, Baillie TA. J Med Chem. 1986 Nov;29(11):2396-9.

Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor - Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor

Ebert B, Mikkelsen S, Thorkildsen C, Borgbjerg FM. Eur J Pharmacol. 1997 Aug 20;333(1):99-104.

Oral ketamine is antinociceptive in the rat formalin test: role of the - Oral ketamine is antinociceptive in the rat formalin test: role of the

Shimoyama M, Shimoyama N, Gorman AL, Elliott KJ, Inturrisi CE. Pain. 1999 May;81(1-2):85-93.