Noscapine hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 5369
• Prices: $95.00
• Sizes: 100 mg
• Cas Number: 912-60-7
• Chemical Name: (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranonehydrochloride
• Formula: C22H23NO7.HCl
• Molecular Weight: 449.88
• Purity: >99 %
• Description: Opioid alkaloid with several actions. Binds to tubulin, arrests cells in mitosis and induces apoptosis. Antagonist at bradykinin receptors (pA 2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues. Modulates IKK activation, suppressing the NF- κ B signaling pathway. Blocks proliferation of human leukemia and multiple myeloma cells. Exhibits anti-inflammatory activity.

Product References

[3H]noscapine binding sites in brain: relationship to indoleamines and the - [3H]noscapine binding sites in brain: relationship to indoleamines and the

Mourey RJ, Dawson TM, Barrow RK, Enna AE, Snyder SH. Mol Pharmacol. 1992 Oct;42(4):619-26.

Efffect of noscapine, the antitussive opioid alkaloid, on bradykinin-induced - Efffect of noscapine, the antitussive opioid alkaloid, on bradykinin-induced

Mahmoudian M, Mojaverian N. Acta Physiol Hung. 2001;88(3-4):231-7.

Noscapine alters microtubule dynamics in living cells and inhibits the - Noscapine alters microtubule dynamics in living cells and inhibits the

Landen JW, Lang R, McMahon SJ, Rusan NM, Yvon AM, Adams AW, Sorcinelli MD, Campbell R, Bonaccorsi P, Ansel JC, Archer DR, Wadsworth P, Armstrong CA, Joshi HC. Cancer Res. 2002 Jul 15;62(14):4109-14.

Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to - Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to

Sung B, Ahn KS, Aggarwal BB. Cancer Res. 2010 Apr 15;70(8):3259-68.