NPS 2143 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0593
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 324523-20-8
• Chemical Name: 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino-2-hydroxypropoxy]benzonitrilehydrochloride
• Formula: C24H25ClNO2.HCl
• Molecular Weight: 445.38
• Purity: >99 %
• Description: Selective Ca 2+ -sensing receptor antagonist. Blocks increases in cytoplasmic Ca 2+ concentrations elicited by human Ca 2+ receptors expressed in HEK293 cells (IC 50 = 43 nM). Also stimulates parathyroid hormone secretion from bovine parathyroid cells (EC 50 = 41 nM). Orally active calcilytic compound.

Product References

Calcilytic compounds: potent and selective Ca2+ receptor antagonists that - Calcilytic compounds: potent and selective Ca2+ receptor antagonists that

Nemeth EF, Delmar EG, Heaton WL, Miller MA, Lambert LD, Conklin RL, Gowen M, Gleason JG, Bhatnagar PK, Fox J. J Pharmacol Exp Ther. 2001 Oct;299(1):323-31.

The search for calcium receptor antagonists (calcilytics). - The search for calcium receptor antagonists (calcilytics).

Nemeth EF. J Mol Endocrinol. 2002 Aug;29(1):15-21.

Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a - Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a

Huang Y, Breitwieser GE. J Biol Chem. 2007 Mar 30;282(13):9517-25. Epub 2007 Feb 6.