NPS 2390

• Supplier: Tocris Bioscience
• Catalog: 3626
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 226878-01-9
• Chemical Name: N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide
• Formula: C19H21N3O
• Molecular Weight: 307.39
• Purity: >99 %
• Description: Group I mGlu antagonist; displays noncompetitive antagonist activity at both mGlu 1 and mGlu 5 receptors. Thought to act on a site separate from the glutamate binding pocket.

Product References

[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a - [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a

Lavreysen H, Janssen C, Bischoff F, Langlois X, Leysen JE, Lesage AS. Mol Pharmacol. 2003 May;63(5):1082-93.

Synthesis, structure-activity relationship, and receptor pharmacology of a new - Synthesis, structure-activity relationship, and receptor pharmacology of a new

Mabire D, Coupa S, Adelinet C, Poncelet A, Simonnet Y, Venet M, Wouters R, Lesage AS, Van Beijsterveldt L, Bischoff F. J Med Chem. 2005 Mar 24;48(6):2134-53.