NPY 5RA972

Name	NPY 5RA972
Supplier	Tocris Bioscience
Catalog	3285
Prices	$189.00, $765.00
Sizes	10 mg, 50 mg
Function Type	Antagonist
Cas Number	439861-56-0
Chemical Name	N-[4-Methyl-9-(1-methylethyl)-9H-carbazol-3-yl]-4-morpholinecarboxamide
Formula	C21H25N3O2
Molecular Weight	351.44
Purity	>98 %
Description	Potent and selective neuropeptide Y Y 5 receptor antagonist (IC 50 values are 3.1, >10000, >10000 and >10000 nM for Y 5 , Y 1 , Y 2 and Y 4 receptors respectively). Does not block NPY-induced feeding in vivo . Orally active and brain penetrant.
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Product References

Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for - Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for

Block MH, Boyer S, Brailsford W, Brittain DR, Carroll D, Chapman S, Clarke DS, Donald CS, Foote KM, Godfrey L, Ladner A, Marsham PR, Masters DJ, Mee CD, O'Donovan MR, Pease JE, Pickup AG, Rayner JW, Roberts A, Schofield P, Suleman A, Turnbull AV. J Med Chem. 2002 Aug 1;45(16):3509-23.

Selective antagonism of the NPY Y5 receptor does not have a major effect on - Selective antagonism of the NPY Y5 receptor does not have a major effect on

Turnbull AV, Ellershaw L, Masters DJ, Birtles S, Boyer S, Carroll D, Clarkson P, Loxham SJ, McAulay P, Teague JL, Foote KM, Pease JE, Block MH. Diabetes. 2002 Aug;51(8):2441-9.

Neuropeptide Y suppresses absence seizures in a genetic rat model primarily - Neuropeptide Y suppresses absence seizures in a genetic rat model primarily

Morris MJ, Gannan E, Stroud LM, Beck-Sickinger AG, O'Brien TJ. Eur J Neurosci. 2007 Feb;25(4):1136-43.