NQ 301

• Supplier: Tocris Bioscience
• Catalog: 3677
• Prices: $119.00, $505.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 130089-98-4
• Chemical Name: 2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione
• Formula: C18H12ClNO3
• Molecular Weight: 325.75
• Purity: >98 %
• Description: Selective CD45 inhibitor (IC 50 = 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases. Increases phosphorylation of Lck in Jurkat cells and reduces T cell receptor signaling in acitvated splenocytes in vitro . Blocks inflammation in a delayed-type hypersensitivity model in vivo .

Product References

Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and - Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and

Bu X, Deady LW, Finlay GJ, Baguley BC, Denny WA. J Med Chem. 2001 Jun 7;44(12):2004-14.

Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of - Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of

Volynets GP, Chekanov MO, Synyugin AR, Golub AG, Kukharenko OP, Bdzhola VG, Yarmoluk SM. J Med Chem. 2011 Apr 28;54(8):2680-6.