NQTrp

Name NQTrp
Supplier Tocris Bioscience
Catalog 4429
Prices $119.00, $505.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 185351-19-3
Chemical Name N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan
Formula C21H16N2O4
Molecular Weight 360.36
Purity >98 %
Description Potent inhibitor of A β oligomer and fibril formation (IC 50 = 50 nM for formation of fibrils from A β 1-42). Reduces cytotoxicity of A β oligomers and increases cell viability in neuronal cells. Significantly extends lifespan of Drosophila expressing human A β 1-42 .
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Product References

The small molecule NS11021 is a potent and specific activator of Ca2+-activated - The small molecule NS11021 is a potent and specific activator of Ca2+-activated

Bentzen BH, Nardi A, Calloe K, Madsen LS, Olesen SP, Grunnet M. Mol Pharmacol. 2007 Oct;72(4):1033-44. Epub 2007 Jul 16.

NS11021, a novel opener of large-conductance Ca(2+)-activated K(+) channels, - NS11021, a novel opener of large-conductance Ca(2+)-activated K(+) channels,

Kun A, Matchkov VV, Stankevicius E, Nardi A, Hughes AD, Kirkeby HJ, Demnitz J, Simonsen U. Br J Pharmacol. 2009 Nov;158(6):1465-76.

BK channel activation by NS11021 decreases excitability and contractility of - BK channel activation by NS11021 decreases excitability and contractility of

Layne JJ, Nausch B, Olesen SP, Nelson MT. Am J Physiol Regul Integr Comp Physiol. 2010 Feb;298(2):R378-84. doi: