NS 1619

• Supplier: Tocris Bioscience
• Catalog: 4788
• Prices: $205.00
• Sizes: 10 mg
• Function Type: Activator
• Cas Number: 153587-01-0
• Chemical Name: 1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one
• Formula: C15H8F6N2O2
• Molecular Weight: 362.23
• Purity: >98 %
• Description: Large-conductance Ca 2+ -activated potassium (BK Ca , K Ca 1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC 50 = 3.6 μ M).

Product References

Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone. - Selective activation of Ca(2+)-dependent K+ channels by novel benzimidazolone.

Olesen SP, Munch E, Moldt P, Drejer J. Eur J Pharmacol. 1994 Jan 4;251(1):53-9.

Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of - Large-conductance K+ channel openers NS1619 and NS004 as inhibitors of

Debska G, Kicinska A, Dobrucki J, Dworakowska B, Nurowska E, Skalska J, Dolowy K, Szewczyk A. Biochem Pharmacol. 2003 Jun 1;65(11):1827-34.