NS 1643

• Supplier: Tocris Bioscience
• Catalog: 3804
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 448895-37-2
• Chemical Name: N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea
• Formula: C15H10F6N2O3
• Molecular Weight: 380.24
• Purity: >98 %
• Description: Human ether-a-go-go related gene (hERG) K V 11.1 channel activator (EC 50 = 10.5 μ M). Exhibits different molecular mechanisms of action at K V 11.1 (hERG1) and K V 11.2 (hERG2) channels. Displays antiarrhythmic activity in vitro .

Product References

Mechanism of action of a novel human ether-a-go-go-related gene channel - Mechanism of action of a novel human ether-a-go-go-related gene channel

Casis O, Olesen SP, Sanguinetti MC. Mol Pharmacol. 2006 Feb;69(2):658-65. Epub 2005 Nov 11.

Activation of human ether-a-go-go-related gene potassium channels by the - Activation of human ether-a-go-go-related gene potassium channels by the

Hansen RS, Diness TG, Christ T, Demnitz J, Ravens U, Olesen SP, Grunnet M. Mol Pharmacol. 2006 Jan;69(1):266-77. Epub 2005 Oct 11.

Activation of ERG2 potassium channels by the diphenylurea NS1643. - Activation of ERG2 potassium channels by the diphenylurea NS1643.

Elmedyb P, Olesen SP, Grunnet M. Neuropharmacology. 2007 Aug;53(2):283-94. Epub 2007 May 21.