NS 2028

• Supplier: Tocris Bioscience
• Catalog: 5276
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 204326-43-2
• Chemical Name: 8-Bromo-1H,4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
• Formula: C9H5BrN2O3
• Molecular Weight: 269.05
• Purity: >98 %
• Description: Potent soluble guanylyl cyclase (sGC) inhibitor (K i = 8 nM). Blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC 50 values are 17 and 20 nM respectively). Inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).

Product References

Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. - Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase.

Olesen SP, Drejer J, Axelsson O, Moldt P, Bang L, Nielsen-Kudsk JE, Busse R, Mulsch A. Br J Pharmacol. 1998 Jan;123(2):299-309.

The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial - The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial

Morbidelli L, Pyriochou A, Filippi S, Vasileiadis I, Roussos C, Zhou Z, Loutrari H, Waltenberger J, Stossel A, Giannis A, Ziche M, Papapetropoulos A. Am J Physiol Regul Integr Comp Physiol. 2010 Mar;298(3):R824-32. doi:

Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of - Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of

von Wantoch Rekowski M, Pyriochou A, Papapetropoulos N, Stossel A, Papapetropoulos A, Giannis A. Bioorg Med Chem. 2010 Feb;18(3):1288-96.