NS 309

• Supplier: Tocris Bioscience
• Catalog: 4517
• Prices: $95.00, $349.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 18711-16-5
• Chemical Name: 6,7-Dichloro-1H-indole-2,3-dione3-oxime
• Formula: C8H4Cl2N2O2
• Molecular Weight: 231.04
• Purity: >98 %
• Description: Positive modulator of small- and intermediate- conductance Ca 2+ -activated K + channels (K Ca 2 and K Ca 3.1 channels); increases Ca 2+ sensitivity. Displays no activity at BK channels.

Product References

2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetam - 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetam

Kuwano K, Hashino A, Asaki T, Hamamoto T, Yamada T, Okubo K, Kuwabara K. J Pharmacol Exp Ther. 2007 Sep;322(3):1181-8. Epub 2007 Jun 1.

A long-acting and highly selective prostacyclin receptor agonist prodrug, - A long-acting and highly selective prostacyclin receptor agonist prodrug,

Kuwano K, Hashino A, Noda K, Kosugi K, Kuwabara K. J Pharmacol Exp Ther. 2008 Sep;326(3):691-9.

Selexipag: a selective prostacyclin receptor agonist that does not affect rat - Selexipag: a selective prostacyclin receptor agonist that does not affect rat

Morrison K, Ernst R, Hess P, Studer R, Clozel M. J Pharmacol Exp Ther. 2010 Oct;335(1):249-55.