NS 3623

• Supplier: Tocris Bioscience
• Catalog: 3895
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 343630-41-1
• Chemical Name: N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea
• Formula: C15H10BrF3N6O
• Molecular Weight: 427.18
• Purity: >99 %
• Description: K V 11.1 (hERG) and K V 4.3 channel activator. Activates the I Kr and I to currents and displays antiarrhythmic activity. May also act as a partial blocker of K V 11.1 channels. Displays selectivity over the key cardiac potassium channels, K V 7.1 (KCNQ1) and K V 1.5. Suitable for both in vitro and in vivo use.

Product References

Biophysical characterization of the new human ether-a-go-go-related gene channel - Biophysical characterization of the new human ether-a-go-go-related gene channel

Hansen RS, Diness TG, Christ T, Wettwer E, Ravens U, Olesen SP, Grunnet M. Mol Pharmacol. 2006 Oct;70(4):1319-29. Epub 2006 Jul 6.

Pharmacological activation of rapid delayed rectifier potassium current - Pharmacological activation of rapid delayed rectifier potassium current

Hansen RS, Olesen SP, Grunnet M. J Pharmacol Exp Ther. 2007 Jun;321(3):996-1002. Epub 2007 Feb 26.

Restoring repolarization in LQT3. - Restoring repolarization in LQT3.

George AL Jr. Heart Rhythm. 2009 Jan;6(1):107-8.