NS 398

Name NS 398
Supplier Tocris Bioscience
Catalog 4831
Prices $175.00, $709.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 123653-11-2
Chemical Name N-[2-Cyclohexyloxy-4-nitrophenyl]methanesulfonamide
Formula C13H18N2O5S
Molecular Weight 314.36
Purity >99 %
Description Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo .
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Product References

NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and - NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and

Futaki N, Yoshikawa K, Hamasaka Y, Arai I, Higuchi S, Iizuka H, Otomo S. Gen Pharmacol. 1993 Jan;24(1):105-10.

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H - NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H

Futaki N, Takahashi S, Yokoyama M, Arai I, Higuchi S, Otomo S. Prostaglandins. 1994 Jan;47(1):55-9.

The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced - The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced

Elder DJ, Halton DE, Playle LC, Paraskeva C. Int J Cancer. 2002 May 20;99(3):323-7.