NS 5806

• Supplier: Tocris Bioscience
• Catalog: 0942
• Prices: $209.00, $879.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 426834-69-7
• Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea
• Formula: C16H8Br2F6N6O
• Molecular Weight: 574.07
• Purity: >99 %
• Description: K V 4.3 channel activator; mediates the transient outward K + current (I to ). Increases I Kv4.3 peak current amplitude in CHO-K1 cells expressing K V 4.3 and KChIP2 (EC 50 = 5.3 μ M). Inhibits K V 1.4-mediated currents independently of KChIP2. Also slows the decay of K V 4.2 and K V 4.3 currents in the presence of KChIP2.

Product References

A transient outward potassium current activator recapitulates the - A transient outward potassium current activator recapitulates the

Calloe K, Cordeiro JM, Di Diego JM, Hansen RS, Grunnet M, Olesen SP, Antzelevitch C. Cardiovasc Res. 2009 Mar 1;81(4):686-94.

Differential effects of the transient outward K(+) current activator NS5806 in - Differential effects of the transient outward K(+) current activator NS5806 in

Calloe K, Soltysinska E, Jespersen T, Lundby A, Antzelevitch C, Olesen SP, Cordeiro JM. J Mol Cell Cardiol. 2010 Jan;48(1):191-200.

Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the - Effect of the I(to) activator NS5806 on cloned K(V)4 channels depends on the

Lundby A, Jespersen T, Schmitt N, Grunnet M, Olesen SP, Cordeiro JM, Calloe K. Br J Pharmacol. 2010 Aug;160(8):2028-44.